CBD oil on Anxiety Disorders – Scientific Evidence

CBD OIl For Anxiety Disorders

Reading about scientific research, results, conclusions and all this stuff can be pretty boring, I know. I can assure you,

CBD Oil Researchwriting about what science has to say on our topic is as boring as reading it.


Since we are talking about health, opinions and personal passions are not as important as scientific evidence. I bet none of you would consume – let’s say- sand to treat a health problem if this weren’t suggested by an expert and there weren’t any scientific studies to support its efficiency.

That’s the purpose of this article; to give scientific support to the articles dealing with each type of anxiety disorder that follow.

Research on CBD oil and its effectiveness on treating various health problems is still in embryonic stage. But there are studies that have already brought evidence on the benefits of CBD oil on anxiety disorders. All five (5) of them !!! And there are a lot more researches being conducted right now!

Uncovering the five major types of anxiety

According to the U.S. Department of Health & Human Services there are five major types of anxiety :CBD Treats Anxiety

  • Generalized Anxiety Disorder or GAD. People with GAD are characterized by chronic anxiety, tend to worry excessively about several things like health, work, every day life, social interactions and tend to feel tension even when there is nothing going wrong. They usually have sleep problems, are irritable and have difficulties to concentrate and control their feelings of worry
  • Panic Disorder. People suffering from Panic Disorder have frequent and unexpected panic attacks. Panic attacks are periods of intense fear accompanied by chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.
  • Obsessive-Compulsive Disorder or OCD. We can characterize an individual as Obsessive-Compulsive when he/she has unwanted, uncontrollable thoughts or else obsessions and/or repetitive behaviors (compulsions). Often compulsions are provoked by the obsessions of the patient. Germ or dirt phobia, extreme need for order, fear of embarrassment are some common obsessions.
  • Social Phobia or Social Anxiety Disorder or SAD. It is characterized by an intense fear of, or anxiety towards, social or performance situations. A common social phobia is a fear of eating or drinking in front of others or speaking in formal and informal situations.
  • Post-Traumatic Stress Disorder or PTSD. People who have experienced a traumatic, shocking, scary, violent or dangerous event can suffer from PTSD.


How does CBD work?

Believe it or not, the human body creates its own cannabinoids which are called endocannabinoids. They help support our regulatory system. This natural endocannabinoid system (ECS) is available in about each cell of the human body and helps to keep our bodies balanced, including: appetite, perception of pain, mood, memory, immune system functions, and inflammation control. Stress recuperation is one of the endocannabinoid system’s primary purposes.

This central system consists of receptor sites found throughout the body, known as the CB1 and CB2 receptors.

As I have already mentioned in a previous post , the majority of CB1 receptors can be found in the brain. These receptors are associated with cognitive actions related to coordination, mood, thinking, memory, and appetite. The CB2 receptors are located in the immune system. This makes them more responsible for the body’s response to pain and inflammation.

CBD is able to interact with CB1 and CB2 receptors due to its similarity to endocannabinoids. CBD itself has a low affinity for both the CB1 and CB2 receptors.

Similar to how we use vitamin C to enhance our immune system, CBD acts as a kick starter for the body’s own cannabinoids to keep the receptors working at optimal capacity and to help the functions of the body’s central regulatory system.

CBD communicates with a neurotransmitter called gamma-aminobutyric corrosive and uses it to transfer the appropriate message from one neuron to another. The message is usually “Back off !!” and since a huge number of neurons react to it, the body obeys and results in lessening anxiety, quieting the sensory system, assisting with rest, unwinding the muscles.

Some scientific evidence

So let’s take a brief look at what science says.

Researchers have discovered CBD can be used as a potential treatment on anxiety disorders because it has anxiolytic, antidepressant and antipsychotic effects. (Related Research Articles 1, 2, 3, 13)

A report, published in 2017, (4 ) presents a number of studies confirming that CBD reduces learned fear response in ways that could be helpful for patients suffering from phobias and PTSD or are former substance users. There is a particular study (5) which gives details on how CBD relieves fear response. According to this study it helps by decreasing fear expression, disrupting memory reconsolidation and enhancing fear extinction. Stop Anxiety With CBD

All the studies agree that CBD helps reduce the impact of learned fears, no matter if you are suffering from phobias, PTSD (6) or other life-changing traumatic experiences.

A 2010 study (10) explored the fear of public speaking in more detail which is a common fear f the social anxiety disorder, The participants were divided in two groups. Group A was given a placebo while group B was given a single dose (600 mg) of CBD oil. 1.5 hours later, both groups were put through a public speaking simulation. The researchers point the following: “Pre-treatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech.”


Homework section

I promised you that it would be a brief look. If you want more, take your time and click the links below. Some of the articles listed have already been used, some others are waiting to be read.

  1. Cannabidiol as a potential treatment for anxiety disorders
  2. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.
  3. Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.
  4. Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders.
  5. Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders.
  6. Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials.
  7. Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders.
  8. Evidences for the Anti-panic Actions of Cannabidiol.
  9. Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?
  10. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.
  11. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.
  12. The endocannabinoid system as a target for novel anxiolytic drugs.
  13. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.
  14. Cannabidiol in Anxiety and Sleep: A Large Case Series.

What to keep in mind

The research in the cannabis area is in its infancy but on the upswing. I think that we have not yet enough information either on its full potential or possible risks and side effects.

Thank you, Ezra, Rachel and Marc for your comments on previous posts. You were the source of inspiration I needed to write this series of articles.

If you have any questions or want to share your personal experience with CBD, leave a comment below.

DISCLAIMER: The content of this article is for informational purposes only. It is not meant to substitute professional medical advice, diagnosis or treatment. The information provided is not meant to alleviate or cure any disease or disorder. Always seek the advice of a qualified health provider for any medical condition.


  1. Hi Effie,

    I think this article is such good news for people with anxiety. It’s so nice to know that there is something out there that could address all 5 different types of anxiety and I’m sure articles like this one give a lot of hope to people who struggle with these things.

    I did a lot of research into legalised cbd oil at one point but over time have forgotten a lot of the benefits so thanks for the refresher! Have you used cbd oil on any ailments eg anxiety/ chronic pain/ immune system etc and if so, did you find it helpful?

    1. Hi Natalie.
      Thank God I don’t suffer from anything like that. I use CBD oil for prevention reasons. My father saw remarkable improvements on his psoriasis and my mother has finally decided to try it for her RA. There is lady in a nearby town that gives CBD to her 21-year -old daughter who has autism problems. I’m planning of interviewing her for more information.

  2. Thank you so much for this great information. It is a shame that the researches haven’t thought about testing CBD before the recent years.

    Marijuana has been around for ages. They were aware of the claims of how it seemed to help those with certain illnesses.

    Why would they not start researching then and also research the effects of CBD versus THC?

    My son and daughter both suffer from anxiety. Actually, 5 of my children suffer from some type of mental issue.

    It is really overwhelming as I myself am fine and have no clue how this can affect all of my children like this.

    Granted they are from 2 separate marriages and both dads passed away. Maybe this is the cause, I am not sure.

    I am just glad that there is something to help those who suffer from mental issues or any health issue.

    Even though there is still more research to be done, it looks like a great alternative to prescription meds that cause side effects.

    The information you have provided will certainly be helpful to many.
    Thank you

    1. Thank YOU Lee Ann for sharing with me. You are right, cannabis has been around for ages. It was used in ancient Greece and by Romans.
      I think it was put aside because of the big pharma business. Prescription meds are a vicious circle. You take one to heal something, their side effects cause you another problem, you take another drug and so on. That’s billions of dollars, don’t you think?

  3. Thanks Effie for the information. Now that Canada has legalized Cannabis I am trying to learn more about the pros and cons of use. You may have already wrote about this before, but if not, I would also like to know more about paranoia and any treatments/research that can assist or help.

  4. Thanks for sharing. I found it particularly interesting that CBD oil could have an impact on social phobias such as fear of speaking in public. I never even knew there was a chemical component to this type of fear. If CBD oil can have such an impact on a broad range of different types of fears and anxieties, and with minimal adverse side effects, the potential is enormous. We’re all being challenged at one time or another in our lives, and the ability to remain calm and dominate our fears and anxieties in the face of challenges can help all of us be more productive and live calmer, more resourceful lives to our benefit, and that of those around us.

    Thanks again, and all the best,


    1. Norman, I think that scientific research hasn’t yet unveiled the full potential of CBD. I believe that we will be amazed by it in the years to come. Research has brought evidence on its benefits to all five major anxiety disorders. It’s our turn now to overcome our skepticism and prejudice and give it a try. 

  5. This is great information. I know research on anything related to marijuana was a no-go for many years. I opened a few of the research articles and noticed they were over the past few years. That’s great that more people are researching this topic. People who struggle with anxiety disorders really need the relief. 

    1. You are so right Nicole. Scientific Research on cannabis is quite intense the last ten years. And, IMHO, will be more intense in the future. As far as people suffering from anxiety disorders are concerned, I honestly think, they should be informed, read some reports and try something that is natural. Sometimes I wonder how can it be possible that someone agrees to take a big pharma medicine, full of chemicals and proven side effects  without a second thought and is so reluctant on trying a natural product. 

  6. I knew that CBD oil is good for a lot of things, including anxiety.  My vet recommended it to my rescue dog who gets anxiety fairly easily.  Well it does work, I know that.  He gets very nervous in certain situations and especially in the car.  I give him his dose of CBD oil, and it helps.  He is relaxed and not jittery.  I think CBD oil is something that a lot of people should consider.  It has so many benefits!

    1. Hello ! I’m grateful for the information you gave us. Personal experience is not just useful, it’s valuable! 

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